SurePac Bio 550 SEC MDi and DNAPac RP Semi-preparative Columns

To support today’s modern laboratories, Thermo Fisher Scientific is introducing several new columns to meet researchers’ analytical, efficiency, and scalability needs

Thermo Fisher Scientific is set to introduce innovative columns at HPLC 2024 to address the analytical, efficiency, and scalability needs of modern laboratories. The new Thermo Scientific™ SurePac™ Bio 550 SEC MDi™ columns are designed for rapid separations of adeno-associated virus (AAV) monomers and aggregates. Additionally, the Thermo Scientific DNAPac™ RP HPLC columns now come in semi-preparative formats, enhancing scalability for DNA/RNA oligonucleotide research and production.

Key Features of SurePac Bio 550 SEC MDi Columns:

• Efficiency and Resolution: Utilizes 3 µm monodisperse particles for superior AAV monomer retention and higher aggregate resolution.
• Reproducibility: MDi technology ensures consistent particle size distribution, offering reliable, reproducible results.
• Higher Throughput: Shorter columns with 3 µm particles enable faster run times, improving throughput compared to traditional 5 µm columns.

Key Applications:

• Ideal for gene-therapy and biopharmaceutical labs requiring size exclusion chromatography (SEC) for AAV aggregate analysis.

Key Features of DNAPac RP Semi-Preparative Columns:

• High Performance: Delivers superior reversed-phase resolution for lab-scale purifications.
• Versatile Analysis: Operates across a wide pH range (0-14) and high temperatures (up to 110 °C).
• Flexible Distribution: Features 4 µm DVB particles with a pore size range up to 2,000 Å, accommodating a variety of nucleic acids, including RNA modalities like intact mRNA.

Key Applications:

• Suitable for laboratories working with synthetic oligonucleotides, siRNA, ASO, and mRNA, providing efficient purification of both small and large DNA and RNA oligonucleotides.

Thermo Fisher's latest columns promise to enhance the efficiency, resolution, and throughput of modern laboratory workflows, supporting the rapid delivery of novel therapeutics.