Future Trends in Immune Cell Therapy: eBook
Written By: Damon Anderson, PhD
Apr 15, 2024
Innovative approaches to improve in vivo efficacy
Genetically modified immune cell therapies use cells that have been engineered to improve their abilities to fight cancer, infectious disease, and other applications. Such approaches have been leveraged to produce T cells, B cells, and natural killer cells that express transgenic T cell receptors (TCRs), chimeric antigen receptors (CARs), and other enhancements. In the case of cancer, the goal of this approach is to improve tumor-specific immunogenicity and to enhance tumor cell killing. Despite
early successes, there are limitations that complicate the development,
testing, and manufacturing of TCR-T, CAR-T, and NK cell therapies. These
include:
- Lack of standard potency assays
to measure biological activity and efficacy
- Suboptimal tumor cell models and
difficulties in solid tumor cell targeting
- Challenges in assessing metabolic
status to improve immune cell activities
This
eBook offers important insight into the state of the industry with a focus on
the latest tools and technologies designed to address the challenges of immune
cell therapy development and testing.