A question of interest, particularly among those searching for health benefits and perhaps worried about the negative side-effects traditionally associated with ‘medicinal marijuana’. The legal status and evolving political disputes have confused the issue even further, making clear evidence-based information about the distinction between the two decidedly opaque.
With the recent FDA approval of the CBD drug Epidiolex, the clinical evidence and the research that is ongoing will provide more comprehensive and decisive information regarding mode of action and biological effects of CBD. This in turn may guide decision making from medical professionals, patients and care givers, and perhaps law makers as well.
Although there are over 100 chemically unique cannabinoids in marijuana, CBD and THC are the clear frontrunners in both relative concentrations and characterization. Before we start, it should be mentioned that a paramount difference between CBD and THC is that the former has no known psychoactive properties, while the latter has pronounced psychoactive effects in the brain.
The most significant difference that belies their isolation is the relative abundance of CBD and THC in specific cannabis plant strains. CBD is found in significantly greater abundance in hemp compared with THC. Hemp is a fibrous plant that grows in stalks, has fewer leaves and an absence of flowers, and displays abundant seed production. The high CBD:THC ratio, coupled with the ability to select for strains with exceedingly low THC profiles, makes CBD isolation from hemp advantageous from a practical (and political/legal) perspective.
As opposed to THC, which is primarily isolated from the flower (specifically the trichromes) of Cannabis sativa or indica, CBD can be isolated from the leaves, seeds, and to a lesser degree, the stalks of hemp. This makes not only the cultivation unique, but plant mass processing, milling, extraction, and the resulting yields of purification different for CBD production as well.
The fact that many groups are now focusing on CBD and hemp processing indicates the markets for hemp related products will see innumerable growth in the foreseeable future.