Automated Protein Characterization at Single-Molecule Level in Solution

New mass photometer with automatic loading and analysis of biomolecular samples, announced

OXFORD, UK — Refeyn, the mass photometry pioneer, has announced the launch of its new Two^MP Auto mass photometer, a unique instrument for the automatic loading and analysis of biomolecular samples for protein characterization at the single-molecule level. Launched at SLAS in Boston, the instrument provides researchers with automated direct mass measurements of up to 14 samples in one hour using the unmatched sensitivity and simplicity of mass photometry—Refeyn’s novel molecular mass measurement technology.

The introduction of the Two^MP Auto closely follows the launch of Refeyn’s Samux^MP benchtop mass photometer for AAV analysis, continuing the company’s momentum in product innovations based on mass photometry. The Two^MP Auto represents a significant shift in protein characterization workflows, enabling scientists to save time and effort through autonomous label-free analysis of biomolecules in solution with minimal sample consumption. Applications of the technology range from purity assessments to interaction analyses. The automation simplifies workflows such as titrations and screening assays, which can be run accurately and reproducibly without operator input, freeing up valuable research time and minimizing the chance of human error.

The Two^MP Auto, which integrates a liquid-handling robot, is operated with Refeyn's Acquire^MP software. Refeyn’s complete software solution enables the user to define the experimental setup, collect data, and analyze and visualize the results. The robotics unit can also be retrofitted to Refeyn’s existing One^MP and Two^MP mass photometers, and is ideal for any task that requires precise, repeated molecular mass characterization and comparison of different conditions or sample compositions.

“We are pleased to continue our new product introductions with the launch of our Two^MP Auto mass photometer for the rapid and autonomous direct measurement of molecular mass in a variety of applications”, said Matthias Langhorst, CPO, Refeyn. “We developed the Two^MP Auto to free up valuable time for scientists and enable labs to work more efficiently.”

Mass photometry is a highly novel tool that is unmatched in its versatility and capability in delivering rapid, simple single-molecule measurement. In addition to offering distinct information on individual particles, mass photometry enables more efficient and effective use of existing specialized technologies, for example, in verifying sample quality prior to cryoEM analysis. The technology also provides significant practical benefits over other methods, such as mass spectrometry, size exclusion chromatography, and surface plasmon resonance by removing the need for labels and providing accurate characterization of biomolecules in solution at the single-molecule level.

To find out more about the Two^MP Auto and mass photometry, please visit https://www.refeyn.com/twomp-auto-mass-photometer.